Herb coming from South Africa. It is traditionally used to treat inflammation. It has anti-inflammatory, anti-rheumatic, analgesic, sedative and diuretic properties. It is traditionally used to treat muscle pain and inflammation.

It is widely used as a popular medicine for the treatment of rheumatic diseases. Subsequent studies have shown that its extracts have good anti-inflammatory and analgesic effects. An evaluation of 15 studies on the pharmacology of Harpagoside concluded that daily doses of at least 50 mg are effective for the treatment of arthritis. Clinical studies confirmed the increase in pain relief for 60% of patients with osteoarthritic hip or knee. Biochemical studies have clarified the mechanism of action of pure Harpagoside, showing that moderately inhibited cyclooxygenase 1 and 2 of the arachidonic acid pathway (COX - 1/2) and total nitric oxide production in human blood. COX 1 and 2 are key enzymes in the arachidonic acid pathway, and inhibitors of these cyclooxygenases have been shown to affect rheumatoid arthritis.

It is one of the most powerful natural anti-inflammatory and analgesic products.