Melissa has Relaxing and soothing properties. Anticonvulsant, anti-inflammatory and antimicrobial action. It stimulates the circulatory system causing vasodilatation and acts against pain.

The Melissa is also used medically, as a beverage or in the form of an extract.It is used as anxiolytic, mild soothing. In at least one study, it has been found to be effective in reducing stress, although the authors of the study call for further research. The Melissa extract was identified as a potent in vitro (in vitro) GABA transaminase inhibitor, which explains the anxiolytic effects. The main compound responsible for inhibiting the action of GABA transaminase with Melissa, was then found to be rosmarinic acid.

Melissa and its preparations have shown to improve mood and spiritual performance. In this effect it is believed that muscarinic and nicotinic acetylcholine receptors are involved.

Positive results have been obtained in a small clinical trial involving patients with Alzheimer's disease with mild to moderate symptoms. Essential oils obtained from Melissa officinalis (Melissa officinalis) have shown high simultaneous inhibition of the enzymes acetylcholinesterase and butyrylcholinesterase.

Its antibacterial properties have also been scientifically proven, although they are significantly weaker than those derived from a number of other plants studied. The apiculture extract has also been found to have an extremely high antioxidant effect.